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Tolerance in TCR/Cognate Antigen Double-Transgenic Mice Mediated by Incomplete Thymic Deletion and Peripheral Receptor Downregulation
Influenza nucleoprotein (NP)-specific T-cell receptor transgenic mice (F5) were crossed with transgenic mice expressing the cognate antigenic protein under the control of the H- 2K(b) promoter. Double-transgenic mice show negative selection of thymocytes at the CD4(+)8(+)TCR(10) to CD4(+)8(+)TCR(hi)...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Hindawi Publishing Corporation
1995
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275967/ https://ncbi.nlm.nih.gov/pubmed/8924765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/1995/54219 |
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