Position effect variegation and imprinting of transgenes in lymphocytes

Sequences proximal to transgene integration sites are able to deregulate transgene expression resulting in complex position effect phenotypes. In addition, transgenes integrated as repeated arrays are susceptible to repeat-induced gene silencing. Using a Cre recombinase-based system we have addresse...

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Detalhes bibliográficos
Main Authors: Williams, Adam, Harker, Nicola, Ktistaki, Eleni, Veiga-Fernandes, Henrique, Roderick, Kathleen, Tolaini, Mauro, Norton, Trisha, Williams, Keith, Kioussis, Dimitris
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367730/
https://ncbi.nlm.nih.gov/pubmed/18296483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn085
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