Position effect variegation and imprinting of transgenes in lymphocytes

Sequences proximal to transgene integration sites are able to deregulate transgene expression resulting in complex position effect phenotypes. In addition, transgenes integrated as repeated arrays are susceptible to repeat-induced gene silencing. Using a Cre recombinase-based system we have addresse...

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Bibliographische Detailangaben
Hauptverfasser: Williams, Adam, Harker, Nicola, Ktistaki, Eleni, Veiga-Fernandes, Henrique, Roderick, Kathleen, Tolaini, Mauro, Norton, Trisha, Williams, Keith, Kioussis, Dimitris
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2008
Schlagworte:
Molecular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367730/
https://ncbi.nlm.nih.gov/pubmed/18296483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn085
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