Tolerance in TCR/Cognate Antigen Double-Transgenic Mice Mediated by Incomplete Thymic Deletion and Peripheral Receptor Downregulation

Influenza nucleoprotein (NP)-specific T-cell receptor transgenic mice (F5) were crossed with transgenic mice expressing the cognate antigenic protein under the control of the H- 2K(b) promoter. Double-transgenic mice show negative selection of thymocytes at the CD4(+)8(+)TCR(10) to CD4(+)8(+)TCR(hi)...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Mamalaki, Clio, Murdjeva, Marianna, Tolaini, Mauro, Norton, Trisha, Chandler, Phillip, Townsend, Alain, Simpson, Elizabeth, Kioussis, Dimitris
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275967/
https://ncbi.nlm.nih.gov/pubmed/8924765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/1995/54219
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados