Positive and Negative Selection in Transgenic Mice Expressing a T-Cell Receptor Specific for Influenza Nucleoprotein and Endogenous Superantigen

A transgenic mouse was generated expressing on most (>80%) of thymocytes and peripheral T cells a T-cell receptor isolated from a cytotoxic T-cell clone (F5). This clone is CD8(+) and recognizes αα366-374 of the nucleoprotein (NP 366-374) of influenza virus (A/NT/60/68), in the context of Class ,...

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Bibliographic Details
Main Authors: Mamalaki, Clio, Elliott, James, Norton, Trisha, Yannoutsos, Nicholas, Townsend, Alain R., Chandler, Phillip, Simpson, Elizabeth, Kioussis, Dimitris
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 1993
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275926/
https://ncbi.nlm.nih.gov/pubmed/8281031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/1993/98015
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