Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms

BACKGROUND: Thyroid receptors, TRα and TRβ, are involved in important physiological functions such as metabolism, cholesterol level and heart activities. Whereas metabolism increase and cholesterol level lowering could be achieved by TRβ isoform activation, TRα activation affects heart rates. Theref...

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Autori principali: Bleicher, Lucas, Aparicio, Ricardo, Nunes, Fabio M, Martinez, Leandro, Gomes Dias, Sandra M, Figueira, Ana Carolina Migliorini, Santos, Maria Auxiliadora Morim, Venturelli, Walter H, da Silva, Rosangela, Donate, Paulo Marcos, Neves, Francisco AR, Simeoni, Luiz A, Baxter, John D, Webb, Paul, Skaf, Munir S, Polikarpov, Igor
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275733/
https://ncbi.nlm.nih.gov/pubmed/18237438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-8-8
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