Gaining ligand selectivity in thyroid hormone receptors via entropy

Nuclear receptors are important targets for pharmaceuticals, but similarities between family members cause difficulties in obtaining highly selective compounds. Synthetic ligands that are selective for thyroid hormone (TH) receptor β (TRβ) vs. TRα reduce cholesterol and fat without effects on heart...

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Bibliografische gegevens
Hoofdauteurs: Martínez, Leandro, Nascimento, Alessandro S., Nunes, Fabio M., Phillips, Kevin, Aparicio, Ricardo, Dias, Sandra Martha G., Figueira, Ana Carolina M., Lin, Jean H., Nguyen, Phuong, Apriletti, James W., Neves, Francisco A. R., Baxter, John D., Webb, Paul, Skaf, Munir S., Polikarpov, Igor
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2009
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791634/
https://ncbi.nlm.nih.gov/pubmed/19926848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911024106
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