Gaining ligand selectivity in thyroid hormone receptors via entropy

Nuclear receptors are important targets for pharmaceuticals, but similarities between family members cause difficulties in obtaining highly selective compounds. Synthetic ligands that are selective for thyroid hormone (TH) receptor β (TRβ) vs. TRα reduce cholesterol and fat without effects on heart...

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Detalhes bibliográficos
Main Authors: Martínez, Leandro, Nascimento, Alessandro S., Nunes, Fabio M., Phillips, Kevin, Aparicio, Ricardo, Dias, Sandra Martha G., Figueira, Ana Carolina M., Lin, Jean H., Nguyen, Phuong, Apriletti, James W., Neves, Francisco A. R., Baxter, John D., Webb, Paul, Skaf, Munir S., Polikarpov, Igor
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791634/
https://ncbi.nlm.nih.gov/pubmed/19926848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911024106
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