Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms

BACKGROUND: Thyroid receptors, TRα and TRβ, are involved in important physiological functions such as metabolism, cholesterol level and heart activities. Whereas metabolism increase and cholesterol level lowering could be achieved by TRβ isoform activation, TRα activation affects heart rates. Theref...

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Detalhes bibliográficos
Main Authors: Bleicher, Lucas, Aparicio, Ricardo, Nunes, Fabio M, Martinez, Leandro, Gomes Dias, Sandra M, Figueira, Ana Carolina Migliorini, Santos, Maria Auxiliadora Morim, Venturelli, Walter H, da Silva, Rosangela, Donate, Paulo Marcos, Neves, Francisco AR, Simeoni, Luiz A, Baxter, John D, Webb, Paul, Skaf, Munir S, Polikarpov, Igor
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275733/
https://ncbi.nlm.nih.gov/pubmed/18237438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-8-8
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