Molecular Dynamics Simulations Reveal Multiple Pathways of Ligand Dissociation from Thyroid Hormone Receptors

Nuclear receptor (NR) ligands occupy a pocket that lies within the core of the NR ligand-binding domain (LBD), and most NR LBDs lack obvious entry/exit routes upon the protein surface. Thus, significant NR conformational rearrangements must accompany ligand binding and release. The precise nature of...

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Autori principali: Martínez, Leandro, Sonoda, Milton T., Webb, Paul, Baxter, John D., Skaf, Munir S., Polikarpov, Igor
Natura: Artigo
Lingua:Inglês
Pubblicazione: Biophysical Society 2005
Soggetti:
Proteins
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366704/
https://ncbi.nlm.nih.gov/pubmed/15980170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.063818
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