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Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1
BACKGROUND AND PURPOSE: In gastrointestinal smooth muscle cGMP levels in response to relaxant agonists are regulated by PKG-mediated phosphorylation and activation of phosphodiesterase 5 (PDE5). The aim of the present study was to determine whether contractile agonists modulate cGMP levels by cross-...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275441/ https://ncbi.nlm.nih.gov/pubmed/18204475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707686 |
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