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Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1

BACKGROUND AND PURPOSE: In gastrointestinal smooth muscle cGMP levels in response to relaxant agonists are regulated by PKG-mediated phosphorylation and activation of phosphodiesterase 5 (PDE5). The aim of the present study was to determine whether contractile agonists modulate cGMP levels by cross-...

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Bibliografske podrobnosti
Glavni avtor: Murthy, K S
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275441/
https://ncbi.nlm.nih.gov/pubmed/18204475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707686
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