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Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
A diverse T cell repertoire is essential for a vigorous immune response to new infections, and decreasing repertoire diversity has been implicated in the age-associated decline in CD8 T cell immunity. In this study, using the well-characterized mouse influenza virus model, we show that although comp...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275391/ https://ncbi.nlm.nih.gov/pubmed/18332179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071140 |
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