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Clonal expansions and loss of receptor diversity in the naïve CD8 T cell repertoire of aged mice
There are well-characterized age-related changes in the peripheral repertoire of CD8 T cells, characterized by reductions in the ratio of naïve to memory T cells and the development of large clonal expansions in the memory pool. In addition, the TCR repertoire of naïve T cells is reduced with aging....
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2724652/ https://ncbi.nlm.nih.gov/pubmed/19124721 |
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