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Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice

Serglycin (SG), the hematopoietic cell secretory granule proteoglycan, is crucial for storage of specific secretory proteins in mast cells, neutrophils, and cytotoxic T lymphocytes. We addressed the role of SG in platelets using SG(−/−) mice. Wild-type (WT) but not SG(−/−) platelets contained chondr...

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Bibliographische Detailangaben
Hauptverfasser: Woulfe, Donna S., Lilliendahl, Joanne Klimas, August, Shelley, Rauova, Lubica, Kowalska, M. Anna, Åbrink, Magnus, Pejler, Gunnar, White, James G., Schick, Barbara P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275015/
https://ncbi.nlm.nih.gov/pubmed/18094327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-104703
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