Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice

Serglycin (SG), the hematopoietic cell secretory granule proteoglycan, is crucial for storage of specific secretory proteins in mast cells, neutrophils, and cytotoxic T lymphocytes. We addressed the role of SG in platelets using SG(−/−) mice. Wild-type (WT) but not SG(−/−) platelets contained chondr...

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Главные авторы: Woulfe, Donna S., Lilliendahl, Joanne Klimas, August, Shelley, Rauova, Lubica, Kowalska, M. Anna, Åbrink, Magnus, Pejler, Gunnar, White, James G., Schick, Barbara P.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2008
Предметы:
Hemostasis, Thrombosis, and Vascular Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275015/
https://ncbi.nlm.nih.gov/pubmed/18094327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-104703
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