Serglycin Proteoglycan Promotes Apoptotic versus Necrotic Cell Death in Mast Cells

The mechanisms that govern whether a cell dies by apoptosis or necrosis are not fully understood. Here we show that serglycin, a secretory granule proteoglycan of hematopoietic cells, can have a major impact on this decision. Wild type and serglycin(−/−) mast cells were equally sensitive to a range...

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Bibliographic Details
Main Authors: Melo, Fabio R., Grujic, Mirjana, Spirkoski, Jane, Calounova, Gabriela, Pejler, Gunnar
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365731/
https://ncbi.nlm.nih.gov/pubmed/22493512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.344796
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