Involvement of the N-terminus of Kir6.2 in coupling to the sulphonylurea receptor

1. ATP-sensitive potassium (K(ATP)) channels are composed of pore-forming Kir6.2 and regulatory SUR subunits. ATP inhibits the channel by interacting with Kir6.2, while sulphonylureas block channel activity by interaction with a high-affinity site on SUR1 and a low-affinity site on Kir6.2. MgADP and...

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Bibliographic Details
Main Authors: Reimann, Frank, Tucker, Stephen J, Proks, Peter, Ashcroft, Frances M
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 1999
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2269423/
https://ncbi.nlm.nih.gov/pubmed/10381582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.1999.0325p.x
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