Identification of a Potent New Chemotype for the Selective Inhibition of PDE4

A series of substituted 3,6-diphenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were prepared and analyzed as inhibitors of phosphodiesterase 4 (PDE4). Synthesis, structure activity relationships and the selectivity of a highly potent analogue against related phosphodiesterase isoforms are present...

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Main Authors: Skoumbourdis, Amanda P., Huang, Ruili, Southall, Noel, Leister, William, Guo, Vicky, Cho, Ming-Hsuang, Inglese, James, Nirenberg, Marshall, Austin, Christopher P., Xia, Menghang, Thomas, Craig J.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268978/
https://ncbi.nlm.nih.gov/pubmed/18243697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.01.028
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