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Identification of a Potent New Chemotype for the Selective Inhibition of PDE4
A series of substituted 3,6-diphenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were prepared and analyzed as inhibitors of phosphodiesterase 4 (PDE4). Synthesis, structure activity relationships and the selectivity of a highly potent analogue against related phosphodiesterase isoforms are present...
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| Hoofdauteurs: | , , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268978/ https://ncbi.nlm.nih.gov/pubmed/18243697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.01.028 |
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