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Ca(2+) oscillation frequency decoding in cardiac cell hypertrophy: Role of calcineurin/NFAT as Ca(2+) signal integrators

The role of Ca(2+) signaling in triggering hypertrophy was investigated in neonatal rat cardiomyocytes in vitro. We show that an increase in cell size and sarcomere reorganization were elicited by receptor agonists such as Angiotensin II, aldosterone, and norepinephrine and by a small rise in medium...

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Bibliographic Details
Main Authors: Colella, Matilde, Grisan, Francesca, Robert, Valerie, Turner, Jay D., Thomas, Andrew P., Pozzan, Tullio
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268550/
https://ncbi.nlm.nih.gov/pubmed/18287024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712316105
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