Balanced interactions of calcineurin with AKAP79 regulate Ca(2+)–calcineurin–NFAT signaling

In hippocampal neurons, the scaffold protein AKAP79 recruits the phosphatase calcineurin to L-type Ca(2+) channels, and couples Ca(2+) influx to activation of calcineurin and of its substrate, the transcription factor NFAT. Here we show that an IAIIIT anchoring site in human AKAP79 binds the same su...

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Hlavní autoři: Li, Huiming, Pink, Matthew D., Murphy, Jonathan G., Stein, Alexander, Dell'Acqua, Mark L., Hogan, Patrick G
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294036/
https://ncbi.nlm.nih.gov/pubmed/22343722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2238
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