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NFAT functions as a working memory of Ca(2+) signals in decoding Ca(2+) oscillation

Transcription by the nuclear factor of activated T cells (NFAT) is regulated by the frequency of Ca(2+) oscillation. However, why and how Ca(2+) oscillation regulates NFAT activity remain elusive. NFAT is dephosphorylated by Ca(2+)-dependent phosphatase calcineurin and translocates from the cytoplas...

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Detalhes bibliográficos
Main Authors: Tomida, Taichiro, Hirose, Kenzo, Takizawa, Azusa, Shibasaki, Futoshi, Iino, Masamitsu
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC169054/
https://ncbi.nlm.nih.gov/pubmed/12881417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg381
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