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CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling
RAF kinase functions in the mitogen-activated protein kinase (MAPK) pathway to transmit growth signals to the downstream kinases MEK and ERK. Activation of RAF catalytic activity is facilitated by a regulatory complex comprising the proteins CNK (Connector enhancer of KSR), HYP (Hyphen), and KSR (Ki...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268546/ https://ncbi.nlm.nih.gov/pubmed/18287031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709705105 |
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