Nalaganje...
Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
The phosphatidylinositol 3-kinase (PI3K) signaling pathway is up-regulated in cancer. PIK3CA, the gene coding for the catalytic subunit p110α of PI3K, is mutated in ≈30% of tumors of the prostate, breast, cervix, and endometrium. The most prominent of these mutants, represented by single amino acid...
Shranjeno v:
| Main Authors: | , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2008
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268191/ https://ncbi.nlm.nih.gov/pubmed/18268322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712169105 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|