Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

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• Hot-spot mutations in p110α of phosphatidylinositol 3-kinase (PI3K): differential interactions with the regulatory subunit p85 and with RAS
  gan: Zhao, Li, et al.
  Cyhoeddwyd: (2010)
• The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells
  gan: Zhao, Jean J., et al.
  Cyhoeddwyd: (2005)
• Gain of interaction with IRS1 by p110α helical domain mutants is crucial for their oncogenic functions
  gan: Hao, Yujun, et al.
  Cyhoeddwyd: (2013)
• Cancer-derived mutations in the regulatory subunit p85α of phosphoinositide 3-kinase function through the catalytic subunit p110α
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  Cyhoeddwyd: (2010)
• The p110α Isoform of Phosphatidylinositol 3-Kinase Is Essential for Polyomavirus Middle T Antigen-Mediated Transformation
  gan: Utermark, Tamara, et al.
  Cyhoeddwyd: (2007)