Cancer-derived mutations in the regulatory subunit p85α of phosphoinositide 3-kinase function through the catalytic subunit p110α

Eitemau Tebyg

• Addition of N-terminal peptide sequences activates the oncogenic and signaling potentials of the catalytic subunit p110α of phosphoinositide-3-kinase
  gan: Sun, Minghao, et al.
  Cyhoeddwyd: (2011)
• Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit
  gan: Yu, Jinghua, et al.
  Cyhoeddwyd: (1998)
• Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling.
  gan: Ueki, Kohjiro, et al.
  Cyhoeddwyd: (2017)
• Hot-spot mutations in p110α of phosphatidylinositol 3-kinase (PI3K): differential interactions with the regulatory subunit p85 and with RAS
  gan: Zhao, Li, et al.
  Cyhoeddwyd: (2010)
• Gα(q) binds to p110α/p85α phosphoinositide 3-kinase and displaces Ras
  gan: Ballou, Lisa M., et al.
  Cyhoeddwyd: (2006)