Cancer-derived mutations in the regulatory subunit p85α of phosphoinositide 3-kinase function through the catalytic subunit p110α

Cancer-specific mutations in the iSH2 (inter-SH2) and nSH2 (N-terminal SH2) domains of p85α, the regulatory subunit of phosphatidylinositide 3-kinase (PI3K), show gain of function. They induce oncogenic cellular transformation, stimulate cellular proliferation, and enhance PI3K signaling. Quantitati...

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Hauptverfasser: Sun, Minghao, Hillmann, Petra, Hofmann, Bianca T., Hart, Jonathan R., Vogt, Peter K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932613/
https://ncbi.nlm.nih.gov/pubmed/20713702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009652107
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