Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds

Proteins that share common ancestry may differ in structure and function because of divergent evolution of their amino acid sequences. For a typical diverse protein superfamily, the properties of a few scattered members are known from experiment. A satisfying picture of functional and structural evo...

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Detalhes bibliográficos
Main Authors: Roessler, Christian G., Hall, Branwen M., Anderson, William J., Ingram, Wendy M., Roberts, Sue A., Montfort, William R., Cordes, Matthew H. J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268138/
https://ncbi.nlm.nih.gov/pubmed/18227506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711589105
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