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Studying protein fold evolution with hybrids of differently folded homologs
To study the sequence determinants governing protein fold evolution, we generated hybrid sequences from two homologous proteins with 40% identity but different folds: Pfl 6 Cro, which has a mixed α + β structure, and Xfaso 1 Cro, which has an all α-helical structure. First, we first examined eight c...
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| Udgivet i: | Protein Eng Des Sel |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4498497/ https://ncbi.nlm.nih.gov/pubmed/25991865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv027 |
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