Formation of amyloid fibrils in vitro by human γD-crystallin and its isolated domains

PURPOSE: Amyloid fibrils are associated with a variety of human protein misfolding and protein deposition diseases. Previous studies have shown that bovine crystallins form amyloid fibers under denaturing conditions and amyloid fibers accumulate in the lens of mice carrying mutations in crystallin g...

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Main Authors: Papanikolopoulou, Katerina, Mills-Henry, Ishara, Thol, Shannon L., Wang, Yongting, Gross, Abby A.R., Kirschner, Daniel A., Decatur, Sean M., King, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Vision 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267726/
https://ncbi.nlm.nih.gov/pubmed/18253099
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