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Folding and stability of the isolated Greek key domains of the long-lived human lens proteins γD-crystallin and γS-crystallin

The transparency of the eye lens depends on the high solubility and stability of the lens crystallin proteins. The monomeric γ-crystallins and oligomeric β-crystallins have paired homologous double Greek key domains, presumably evolved through gene duplication and fusion. Prior investigation of the...

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Autori principali: Mills, Ishara A., Flaugh, Shannon L., Kosinski-Collins, Melissa S., King, Jonathan A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211709/
https://ncbi.nlm.nih.gov/pubmed/17905830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.072970207
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