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Kinetic Stability of Long-Lived Human Lens γ-Crystallins and Their Isolated Double Greek Key Domains

The γ-crystallins of the eye lens nucleus are among the longest-lived proteins in the human body. Synthesized in utero, they must remain folded and soluble throughout adulthood to maintain lens transparency and avoid cataracts. γD- and γS-crystallin are two major monomeric crystallins of the human l...

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Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Mills-Henry, Ishara A., Thol, Shannon L., Kosinski-Collins, Melissa S., Serebryany, Eugene, King, Jonathan A.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700672/
https://ncbi.nlm.nih.gov/pubmed/31266635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.06.006
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