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Formation of Amyloid Fibrils In Vitro from Partially Unfolded Intermediates of Human γC-Crystallin

PURPOSE. Mature-onset cataract results from the formation of light-scattering aggregates of lens crystallins. Although oxidative or mutational damage may be a prerequisite, little is known of the initiation or nucleation of these aggregated states. In mice carrying mutations in γ-crystallin genes, a...

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Bibliografski detalji
Glavni autori: Wang, Yongting, Petty, Sarah, Trojanowski, Amy, Knee, Kelly, Goulet, Daniel, Mukerji, Ishita, King, Jonathan
Format: Artigo
Jezik:Inglês
Izdano: Association for Research in Vision and Ophthalmology, Inc. 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868461/
https://ncbi.nlm.nih.gov/pubmed/19684009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.09-3987
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