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Amyloid Fiber Formation in Human γD-Crystallin Induced by UV-B Photodamage

γD-crystallin is an abundant structural protein of the lens that is found in native and modified forms in cataractous aggregates. We establish that UV-B irradiation of γD-crystallin leads to structurally specific modifications and precipitation via two mechanisms: amorphous aggregates and amyloid fi...

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Detalhes bibliográficos
Main Authors: Moran, Sean D., Zhang, Tianqi O., Decatur, Sean M., Zanni, Martin T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859806/
https://ncbi.nlm.nih.gov/pubmed/23957864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4008353
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