Stabilization of Neurotoxic Soluble β-Sheet-Rich Conformations of the Alzheimer's Disease Amyloid-β Peptide

An emerging paradigm for degenerative diseases associated with protein misfolding, such as Alzheimer's disease, is the formation of a toxic species due to structural transitions accompanied by oligomerization. Increasingly, the focus in Alzheimer's disease is on soluble oligomeric forms of...

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Bibliographic Details
Main Authors: Tew, Deborah J., Bottomley, Stephen P., Smith, David P., Ciccotosto, Giuseppe D., Babon, Jeffrey, Hinds, Mark G., Masters, Colin L., Cappai, Roberto, Barnham, Kevin J.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2008
Subjects:
Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267149/
https://ncbi.nlm.nih.gov/pubmed/18065467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.119909
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