Atomic-Scale Simulations Confirm that Soluble β-Sheet-Rich Peptide Self-Assemblies Provide Amyloid Mimics Presenting Similar Conformational Properties

The peptide self-assembly mimic (PSAM) from the outer surface protein A (OspA) can form highly stable but soluble β-rich self-assembly-like structures similar to those formed by native amyloid-forming peptides. However, unlike amyloids that predominantly form insoluble aggregates, PSAMs are highly w...

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Detalhes bibliográficos
Main Authors: Yu, Xiang, Wang, Jingdai, Yang, Jui-Chen, Wang, Qiuming, Cheng, Stephen Z.D., Nussinov, Ruth, Zheng, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Biophysical Systems and Multicellular Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800962/
https://ncbi.nlm.nih.gov/pubmed/20085717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.10.003
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