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BH3 mimetics to improve cancer therapy; mechanisms and examples
Tumor cell survival is highly dependent on the expression of certain pro-survival Bcl-2 family proteins. An attractive therapeutic approach is to inhibit these proteins using agents that mimic the Bcl-2 homology 3 (BH3) domains of the proapoptotic Bcl-2 family members, which neutralize these protein...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2265791/ https://ncbi.nlm.nih.gov/pubmed/17921043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drup.2007.08.002 |
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