Defining the susceptibility of colorectal cancers to BH3-mimetic compounds

Novel targets are required to improve the outcomes for patients with colorectal cancers. In this regard, the selective inhibitor of the pro-survival protein BCL2, venetoclax, has proven highly effective in several hematological malignancies. In addition to BCL2, potent and highly selective small mol...

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Published in:Cell Death Dis
Main Authors: Luo, Ming-Jie, Palmieri, Michelle, Riffkin, Chris D., Sakthianandeswaren, Anuratha, Djajawi, Tirta Mario, Hirokawa, Yumiko, Shuttleworth, Victoria, Segal, David H., White, Christine A., Nhu, Duong, Lessene, Guillaume, Lee, Margaret, Gibbs, Peter, Huang, David C. S., Sieber, Oliver M., Gong, Jia-nan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483443/
https://ncbi.nlm.nih.gov/pubmed/32913182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02815-0
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