Defining the susceptibility of colorectal cancers to BH3-mimetic compounds

Novel targets are required to improve the outcomes for patients with colorectal cancers. In this regard, the selective inhibitor of the pro-survival protein BCL2, venetoclax, has proven highly effective in several hematological malignancies. In addition to BCL2, potent and highly selective small mol...

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Publicado no:Cell Death Dis
Main Authors: Luo, Ming-Jie, Palmieri, Michelle, Riffkin, Chris D., Sakthianandeswaren, Anuratha, Djajawi, Tirta Mario, Hirokawa, Yumiko, Shuttleworth, Victoria, Segal, David H., White, Christine A., Nhu, Duong, Lessene, Guillaume, Lee, Margaret, Gibbs, Peter, Huang, David C. S., Sieber, Oliver M., Gong, Jia-nan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483443/
https://ncbi.nlm.nih.gov/pubmed/32913182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02815-0
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