Kinetic Analysis in Healthy Humans of a Novel Positron Emission Tomography Radioligand to Image the Peripheral Benzodiazepine Receptor, a Potential Biomarker for Inflammation

The peripheral benzodiazepine receptor (PBR) is upregulated on activated microglia and macrophages and thereby is a useful biomarker of inflammation. We developed a novel PET radioligand, [(11)C]PBR28, that was able to image and quantify PBRs in healthy monkeys and in a rat model of stroke. The obje...

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Главные авторы: Fujita, Masahiro, Imaizumi, Masao, Zoghbi, Sami S., Fujimura, Yota, Farris, Amanda G., Suhara, Tetsuya, Hong, Jinsoo, Pike, Victor W., Innis, Robert B.
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265774/
https://ncbi.nlm.nih.gov/pubmed/18093844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2007.11.011
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