Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium

Effective administration of flavopiridol in advanced-stage chronic lymphocytic leukemia (CLL) is often associated with early biochemical evidence of tumor cell lysis. Previous work using other cell types showed that flavopiridol impacts mitochondria, and in CLL cells flavopiridol down-regulates the...

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Autores principales: Hussain, Syed-Rehan A., Lucas, David M., Johnson, Amy J., Lin, Thomas S., Bakaletz, Alan P., Dang, Vinh X., Viatchenko-Karpinski, Serge, Ruppert, Amy S., Byrd, John C., Kuppusamy, Periannan, Crouser, Elliott D., Grever, Michael R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2008
Materias:
Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265456/
https://ncbi.nlm.nih.gov/pubmed/18192508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-115733
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