Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium

Effective administration of flavopiridol in advanced-stage chronic lymphocytic leukemia (CLL) is often associated with early biochemical evidence of tumor cell lysis. Previous work using other cell types showed that flavopiridol impacts mitochondria, and in CLL cells flavopiridol down-regulates the...

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Detalhes bibliográficos
Main Authors: Hussain, Syed-Rehan A., Lucas, David M., Johnson, Amy J., Lin, Thomas S., Bakaletz, Alan P., Dang, Vinh X., Viatchenko-Karpinski, Serge, Ruppert, Amy S., Byrd, John C., Kuppusamy, Periannan, Crouser, Elliott D., Grever, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265456/
https://ncbi.nlm.nih.gov/pubmed/18192508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-115733
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