Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium

Effective administration of flavopiridol in advanced-stage chronic lymphocytic leukemia (CLL) is often associated with early biochemical evidence of tumor cell lysis. Previous work using other cell types showed that flavopiridol impacts mitochondria, and in CLL cells flavopiridol down-regulates the...

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Autors principals: Hussain, Syed-Rehan A., Lucas, David M., Johnson, Amy J., Lin, Thomas S., Bakaletz, Alan P., Dang, Vinh X., Viatchenko-Karpinski, Serge, Ruppert, Amy S., Byrd, John C., Kuppusamy, Periannan, Crouser, Elliott D., Grever, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2008
Matèries:
Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265456/
https://ncbi.nlm.nih.gov/pubmed/18192508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-115733
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