Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate

Production of Ran–guanosine triphosphate (GTP) around chromosomes induces local nucleation and plus end stabilization of microtubules (MTs). The nuclear protein TPX2 is required for RanGTP-dependent MT nucleation. To find the MT stabilizer, we affinity purify nuclear localization signal (NLS)–contai...

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Autores principales: Yokoyama, Hideki, Gruss, Oliver J., Rybina, Sofia, Caudron, Maïwen, Schelder, Malgorzata, Wilm, Matthias, Mattaj, Iain W., Karsenti, Eric
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2008
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265385/
https://ncbi.nlm.nih.gov/pubmed/18316407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200706189
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