Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate

Production of Ran–guanosine triphosphate (GTP) around chromosomes induces local nucleation and plus end stabilization of microtubules (MTs). The nuclear protein TPX2 is required for RanGTP-dependent MT nucleation. To find the MT stabilizer, we affinity purify nuclear localization signal (NLS)–contai...

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Detalhes bibliográficos
Main Authors: Yokoyama, Hideki, Gruss, Oliver J., Rybina, Sofia, Caudron, Maïwen, Schelder, Malgorzata, Wilm, Matthias, Mattaj, Iain W., Karsenti, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265385/
https://ncbi.nlm.nih.gov/pubmed/18316407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200706189
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