Phenylalanine-508 mediates a cytoplasmic–membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

Deletion of phenylalanine-508 (Phe-508) from the N-terminal nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ATP-binding cassette (ABC) transporter family, disrupts both its folding and function and causes most cystic fibrosis. Most...

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Autors principals: Serohijos, Adrian W. R., Hegedűs, Tamás, Aleksandrov, Andrei A., He, Lihua, Cui, Liying, Dokholyan, Nikolay V., Riordan, John R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265173/
https://ncbi.nlm.nih.gov/pubmed/18305154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800254105
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