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Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule

Stress response pathways allow cells to sense and respond to environmental changes and adverse pathophysiological states. Pharmacological modulation of cellular stress pathways has implications in the treatment of human diseases, including neurodegenerative disorders, cardiovascular disease, and can...

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Autors principals: Trott, Amy, West, James D., Klaić, Lada, Westerheide, Sandy D., Silverman, Richard B., Morimoto, Richard I., Morano, Kevin A.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2262981/
https://ncbi.nlm.nih.gov/pubmed/18199679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-10-1004
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