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Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1
Heat shock factor 1 (HSF1) is essential for protecting cells from protein-damaging stress associated with misfolded proteins and regulates the insulin-signaling pathway and aging. Here, we show that human HSF1 is inducibly acetylated at a critical residue that negatively regulates DNA binding activi...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3429349/ https://ncbi.nlm.nih.gov/pubmed/19229036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1165946 |
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