The SIRT1 Modulators AROS and DBC1 Regulate HSF1 Activity and the Heat Shock Response

The heat shock response, the cellular response to protein damaging stress, is critical in maintaining proteostasis. The heat shock response is regulated by the transcription factor HSF1, which is activated upon heat shock and other stresses to induce the expression of molecular chaperones. SIRT1 has...

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Bibliographic Details
Main Authors: Raynes, Rachel, Pombier, Kathleen M., Nguyen, Kevin, Brunquell, Jessica, Mendez, Jamie E., Westerheide, Sandy D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548779/
https://ncbi.nlm.nih.gov/pubmed/23349863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054364
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