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Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol
Celastrol, an important natural product and Hsp90 inhibitor with a wide range of biological and medical activities and broad use as a biological probe, acts by an as yet undetermined mode of action. It is known to undergo Michael additions with biological sulfur nucleophiles. Here it is demonstrated...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3238675/ https://ncbi.nlm.nih.gov/pubmed/22087583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja208359a |
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