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IFN-γ– and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers
Tumors elicit antitumor immune responses, but over time they evolve and can escape immune control through various mechanisms, including the loss of the antigen to which the response is directed. The escape of antigen-loss variants (ALVs) is a major obstacle to T cell–based immunotherapy for cancer....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2262029/ https://ncbi.nlm.nih.gov/pubmed/18317595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33522 |
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