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Adoptively transferred immune T cells eradicate established tumors in spite of cancer-induced immune suppression

Myeloid-derived CD11b(+)Gr1(+) suppressor cells (MDSC) and tumor-associated macrophages (TAM) are considered a major obstacle for effective adoptive T cell therapy. Myeloid cells suppress naive T cell proliferation ex vivo and can prevent the generation of T cell responses in vivo. We find, however,...

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Hlavní autoři: Arina, Ainhoa, Schreiber, Karin, Binder, David C., Karrison, Theodore, Liu, Rebecca B., Schreiber, Hans
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084557/
https://ncbi.nlm.nih.gov/pubmed/24367029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202498
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