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Adoptively transferred immune T cells eradicate established tumors in spite of cancer-induced immune suppression
Myeloid-derived CD11b(+)Gr1(+) suppressor cells (MDSC) and tumor-associated macrophages (TAM) are considered a major obstacle for effective adoptive T cell therapy. Myeloid cells suppress naive T cell proliferation ex vivo and can prevent the generation of T cell responses in vivo. We find, however,...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4084557/ https://ncbi.nlm.nih.gov/pubmed/24367029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202498 |
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