Alpha/Beta Interferon Inhibits Cap-Dependent Translation of Viral but Not Cellular mRNA by a PKR-Independent Mechanism

The alpha/beta interferon (IFN-α/β) response is critical for host protection against disseminated replication of many viruses, primarily due to the transcriptional upregulation of genes encoding antiviral proteins. Previously, we determined that infection of mice with Sindbis virus (SB) could be con...

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Autores principales: Tesfay, Mulu Z., Yin, Jun, Gardner, Christina L., Khoretonenko, Mikhail V., Korneeva, Nadejda L., Rhoads, Robert E., Ryman, Kate D., Klimstra, William B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2259014/
https://ncbi.nlm.nih.gov/pubmed/18160435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01784-07
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